Differential effects of antiepileptics on hippocampal and pallidal afterdischarges in cats.

Many investigators reported that the hippocampus (HPC) was involved in cerebral and cerebellar seizure discharges and epileptiform phenomena (1-4), and it was the well known site of histological lesion which was found in approximately 50 per cent of epileptic brains (5, 6). The HPC has the lowest threshold of excitability to electrical stimulus of all the cerebral structues so far studied since reported by Kaada (1). Pathologically and electrophysiologically the sensitive structure of brain is suggested to play an essential